Hashirama,Mito,Madara

The Uzumaki and Senju clans — being distant relatives — have always had close ties. Mito ended up marrying Hashirama Senju, who would help found Konohagakure and became the village's First Hokage.During her husband's battle against Madara Uchiha at the Valley of the End, Hashirama at some point gained control of Kurama. To gain power for her husband, Mito used a fūinjutsu to seal Kurama within herself, becoming the tailed beast's first jinchūriki. Despite the seal's strength, it almost broke at some later point when she was going through childbirth. Eventually, her husband died in war, and Mito was left a widow, going into solitude.